Fig. 1: MLL3 regulates cancer cell migration.
From: MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity
A Histogram showing the mutation rates of MLL3 in different types of cancer. Data are from MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017). B Two independent MLL3 knockdown HeLa cell lines were generated with CRISPR/Cas9 system. MLL3 protein levels were examined by western blotting. C Cells were prepared as (B). Cell viability assay was performed to examine the cell proliferation rates after MLL3 depletion. D Cells were prepared as (B) and transwell assay was performed to measure cell migration after MLL3 depletion. E–G Cells were prepared as (B) and injected into nude mice. Tumors were pictured (E). Tumor growth curves (F) and tumor weight (G) were shown as mean ± SEM (n = 6,9,9 respectively). *P < 0.05, **P < 0.01, ***P < 0.001.
