Fig. 1: HOTAIR is upregulated in recurrent GIST tissue and is associated with imatinib sensitivity. | Cell Death & Disease

Fig. 1: HOTAIR is upregulated in recurrent GIST tissue and is associated with imatinib sensitivity.

From: LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway

Fig. 1

A Some of the lncRNAs that were differentially expressed in recurrent GIST tissues compared with that in primary GIST tissues. B Heat map of differentially expressed lncRNAs after imatinib treatment. C Overall survival based on the high expression of HOTAIR in several kinds of gastrointestinal tumors. D The change in HOTAIR expression after transfection, as assessed using qRT-PCR in GIST-T1 and GIST-882 cells. *P < 0.05, **P < 0.01 vs. NC or pEX-3. E, F CCK-8 assays were performed to examine imatinib sensitivity of GIST cells, and the IC50 values are plotted as bar graphs. *P < 0.05, **P < 0.01 vs. NC.

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