Fig. 5: miR-130a directly targets ATG2B. | Cell Death & Disease

Fig. 5: miR-130a directly targets ATG2B.

From: LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway

Fig. 5

A The TargetScan predicted the binding site for miR-130a in the 3′-UTR of ATG2B. B Dual-Luciferase reporter assays analyzing the putative targets of miR-130a. *P < 0.05 vs. h-ATG2B-WT + NC. C, D The results of western blotting and qRT-PCR showing that miR-130a regulates ATG2B in GIST cells. **P < 0.01; ***P < 0.001 vs. the NC or inhibitor NC. E CCK-8 assays were used to measure the changes in cell viability after different transfection of GIST cells. *P < 0.05; **P < 0.01 vs. NC.

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