Fig. 7: The downregulation of HOTAIR increased the sensitivity of GIST cells to imatinib in vivo. | Cell Death & Disease

Fig. 7: The downregulation of HOTAIR increased the sensitivity of GIST cells to imatinib in vivo.

From: LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway

Fig. 7

A Size of the excised tumors after 14 days of treatment with or without imatinib in the presence or absence of siHOTAIR. B Average percent change in tumor volume relative to the beginning for each treatment. *P < 0.05; **P < 0.01 vs. control. C Changes in body weight for each treatment. D, E The relative expression levels of HOTAIR and miR-130a were analyzed in the four groups using qRT-PCR. **P < 0.01 vs. control or imatinib. F The levels of autophagy-related proteins (ATG2B, Beclin1, p62, and LC3) were detected using western blotting. G Representative pictures of Ki-67 staining, TUNEL assays, and immunohistochemistry for p62. H The positive rates of Ki-67 staining and TUNEL assays. **P < 0.01 vs. control. ##P < 0.01 vs. imatinib.

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