Fig. 1: H2O2 induced oxidative damage to 661w cells. | Cell Death & Disease

Fig. 1: H2O2 induced oxidative damage to 661w cells.

From: Mitochondrial quality control protects photoreceptors against oxidative stress in the H2O2-induced models of retinal degeneration diseases

Fig. 1

a, b H2O2 decreased cell viability in a dose- and time-dependent manner. 661w cells were treated with different concentrations of H2O2 for 12 h in (a) (n = 5). 600 μmol/L H2O2 was used to treat 661w cells for different hours in (b) (n = 5). c 661w cells became round and shrunken with 600 μmol/L H2O2 treatment. The morphology changes were irreversible with 800 μmol/L H2O2 treatment. d H2O2 inhibited the activity of SOD and CAT, and decreased the level of GSH (n ≥ 4). e H2O2 increased cellular ROS generation. Data are shown as mean. Scale bar: 100 μm.

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