Fig. 7: Decidualization is augmented by overexpression of ATF3 in RIF patients. | Cell Death & Disease

Fig. 7: Decidualization is augmented by overexpression of ATF3 in RIF patients.

From: ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients

Fig. 7

A hESCs (from fertile controls and RIF patients) were treated with 8-Br-cAMP+MPA for 3 days. Prolactin secretion was measured by ELFA. n = 5, *P < 0.05, **P < 0.01. B, C hESCs from RIF patients were infected with Ad-ATF3-his (0 or 40 MOI) or Ad-LacZ for 48 h followed by treatment with 0.5 mM 8-Br-cAMP and 1 μM MPA for 3 days. Prolactin released into the medium was measured by ELFA and qPCR. n = 4, *P < 0.05, **P < 0.01. D Schematic representation of the role of ATF3 in the regulation of decidualization in RIF patients and fertile control groups.

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