Fig. 8: circBACH2 promoted the progression of TNBC in vivo. | Cell Death & Disease

Fig. 8: circBACH2 promoted the progression of TNBC in vivo.

From: Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer

Fig. 8

MDA-MB-231 cells were transfected with Lv-circBACH2 or Lv-sh-circBACH2 or corresponding controls (Lv-NC or Lv-sh-NC) and subcutaneously injected into the nude mice. A The xenografted tumors photos of mice (n = 6). The tumor B volumes and C weights of mice. ***P < 0.001. MDA-MB-231 cells were transfected with Lv-circBACH2 or Lv-sh-circBACH2 or corresponding controls (Lv-NC or Lv-sh-NC) and transplanted into the nude mice by tail vein injection. n = 6 of each group. D The expression level of circBACH2 in the lung tissues of mice. The expression levels of E miR-186-5p and F miR-548c-3p in the lung tissues of mice. G The CXCR4 protein level in the lung tissues of mice. H Representative HE staining (scale bar = 100 µm) for lung tissues of mice in each group. Arrows: metastatic nodules. ***P < 0.001 vs Lv-NC or Lv-sh-NC. B–F the experiment was repeated three times with tumor samples from six mice.

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