Table 2 Urine and serum analysis of control and Nedd4-2Ksp1.3 mice on low Na+ diet.

From: The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease

Low Na+

  
 

Control

Nedd4-2Ksp1.3

Urine

Osmolarity (mOsmol/kg)

1325.67 ± 207.54 (3)

1125.25 ± 375.00 (4)

Creatinine (Cr) (mM)

4.09 ± 0.43 (9)

1.86 ± 0.28 (7)**

Urea/Cr

532.75 ± 42.96 (8)

559.25 ± 94.06 (4)

Na+/Cr

52.75 ± 8.89 (8)

77.00 ± 11.83 (4)

K+/Cr

115.14 ± 9.88 (8)

138.88 ± 17.10 (4)

Cl−/Cr

64.63 ± 9.52 (8)

91.25 ± 11.92 (4)

Ca2+/Cr

0.83 ± 0.13 (8)

4.27 ± 0.93* (4)

Protein/Cr

1199.63 ± 163.98 (8)

1216.50 ± 231.60 (4)

Serum

Na+ (mM)

151.44 ± 0.96 (9)

152.29 ± 1.38 (7)

K+ (mM)

8.40 ± 0.24 (9)

8.93 ± 0.40 (7)

Cl− (mM)

104.67 ± 0.60 (9)

103.57 ± 1.17 (7)

Ca2+ (mM)

2.66 ± 0.03 (9)

2.60 ± 0.06 (7)

HCO3− (mM)

24.56 ± 0.82 (9)

22.42 ± 1.45 (7)

Glucose (mM)

12.88 ± 0.34 (9)

12.83 ± 0.42 (7)

Globulin (g/L)

39.78 ± 0.64 (9)

41.14 ± 0.63 (7)

Albumin (g/L)

16.00 ± 0.37 (9)

16.86 ± 0.51 (7)

Protein (g/L)

55.78 ± 0.86 (9)

58.00 ± 0.98 (7)

Aldosterone (pmol/L)

99.39 ± 25.82 (5)

49.34 ± 11.12 (4)

  1. Data presented as mean ± SEM for a number of mice (n) indicated in parentheses. Significance was determined using a Mann–Whitney test for non-normally distributed data. *P < 0.05, **P < 0.01.
  2. Bold values indicate statistical significance.
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