Fig. 4: The signaling Niche of urothelium regeneration. | Cell Death & Disease

Fig. 4: The signaling Niche of urothelium regeneration.

From: Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury

Fig. 4

A Dot plot show top5 interactions from each non-epithelial cell types to epithelial cells predicted by CellphoneDB. B Schematic representation of the NicheNet analysis of ligands’ influence on cell cycle entry. Ligands were predicted by CellphoneDB and the top12 potential ligands were showed. Left, heatmap show the ligands activity. Middle, heatmap show the average expression of ligands in each cell type under each condition. Right, heatmap show the potential target genes and the regulatory potential of each activated ligands. C Heatmap show the sum of intensity of all communications from non-epithelial cells to urothelium (top), and communications predicted to influence cell cycle entry by NicheNet algorithm (bottom). The numbers showed on the heatmap were the sum of intensity.

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