Fig. 6: Cell-cell communication network regulates urothelial regeneration. | Cell Death & Disease

Fig. 6: Cell-cell communication network regulates urothelial regeneration.

From: Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury

Fig. 6

A Dot plot shows specific ligand-receptor pairs between mesenchymal cells and epithelial cells in three conditions. B Schematic showing experimental design for assessing proliferating inhibition by Fgf-signaling blocking. C Immunostainings of Krt5 (in red) and Ki67 (in green) on sections of control (left) and BGJ398 treatment (right) CPP-injured bladder (scale bar 50 microns). D Bar plot shows the percentage of Ki67 positive cells in urothelial cells (n = 15 per condition, mean with SD, t-test, ****p < 0.0001). E Diagram of the main ligand-receptor interactions worked in bladder regeneration.

Back to article page