Fig. 2: Differential microRNA expression in benign nevi (BN), cutaneous melanoma (CM), and in multiple primary melanoma (MPM).
From: Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis
Box and whiskers graph representation of nine microRNAs differentially expressed in single and multiple primary melanomas (P < 0.05). MPM shows higher expression levels of miR-205-5p, miR-200b-3p, and miR-149-5p compared to CM, and higher expression of miR-92b-3p compared to BN. MPM downregulates miR-21-5p compared to CM and miR-146a-5p compared to CM and BN. BN upregulates miR-25-3p and miR-211-5p compared to CM and MPM. Each miRNA was tested in triplicate by quantitative RT-PCR. Relative miRNA expression was normalized on invariant miR-16-5p. The bar shows minimum and maximum values; superimposed points represent all individual values.
