Fig. 4: MetaCore pathway analysis showing the involvement of differently expressed miRNAs in epithelial–mesenchymal transition (EMT).
From: Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis
EMT pathway representation with regulating miRNAs. Log ratio of miRNA expression level in CM/BN (1), MPM/BN (2), and MPM/CM (3) is visualized on the maps as a thermometer-like figure. Upward thermometers have a red color and indicate upregulated signals, and downward (blue) ones indicate downregulated expression level of specific microRNAs. “M” indicates microRNA binding (regulation of gene expression by binding of microRNA to target mRNA), whereas “TR” indicates Transcription regulation (physical binding of a transcription factor to target gene’s promoter). MPM showed higher expression levels of microRNAs involved in the inhibition of epithelial–mesenchymal transition (EMT), including miR-205-5p and miR-200b-3p. (BN, benign nevi; CM, cutaneous melanoma; MPM multiple primary melanoma).
