Fig. 6: Canonical hsa-miR-125a-5p|0|0) and hsa-miR-125a-5p|0|−2 isomiR expression across 32 TCGA tumor types.
From: Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis
miR-125a isomiR is most expressed in many cancer types. Box and whiskers graphs of canonical and shorter isoform of miR-125a-5p show variable expression levels, represented here as log2 RPKM data, across 32 different cancer type. miR-125a-5p isoform is most abundant in many cancer types and shows a specifically high canonical/isoform ratio in the melanoma (SKCM) group. The bar shows 1–99 percentile values. TCGA abbreviations: ACC, adrenocortical carcinoma; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, cholangiocarcinoma; COAD, colon adenocarcinoma; DLBC, lymphoid neoplasm diffuse large B-cell lymphom; ESCA, esophageal carcinoma; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LAML, acute myeloid leukemia; LGG, brain lower grade glioma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; MESO, mesothelioma; OV, ovarian serous cystadenocarcinoma; PAAD, pancreatic adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; PRAD, prostate adenocarcinoma; READ, rectum adenocarcinoma; SARC, sarcoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; TGCT, testicular germ cell tumors; THCA, thyroid carcinoma; THYM, thymoma; UCEC, uterine corpus endometrial carcinoma; UCS, uterine carcinosarcoma; UVM, uveal melanoma.
