Fig. 7: Overexpression of MAPK14 partly reverses the effects of sh-circACSL1. | Cell Death & Disease

Fig. 7: Overexpression of MAPK14 partly reverses the effects of sh-circACSL1.

From: Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression

Fig. 7

A–F The circACSL1-knockdown cell lines were co-transfected with MAPK14 overexpression vectors, which were compared with circACSL1-knockdown cells alone. A The overexpression efficiency of MAPK14 was detected by qRT-PCR. B Overexpression of MAPK14 abolished the suppressive effects of sh-circACSL1 on HCM cell proliferation. C, D Sh-circACSL1-induced downregulation of IL-1β, IL-6, TNF-α, cTnT, CKMB, and BNP were rescued by co-transfection with MAPK14 overexpression vectors and sh-circACSL1. E, F Sh-circACSL1-induced decrease of cell apoptosis was reversed by co-transfection with MAPK14 overexpression vectors and sh-circACSL1. Data are presented as mean ±SD (n = 3 biologically independent samples). *p < 0.05; **p < 0.01; ***p < 0.001 (Student’s t test).

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