Fig. 4: Bioinformatics analysis reveals the landscape of bufalin-regulated signaling networks.
From: Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma
a Distribution of cellular component categories for differential proteins significantly altered by bufalin. b Distribution of biological process categories for differential proteins substantially affected by bufalin. c Distribution of molecular function categories for differential proteins dramatically changed by bufalin. d Network diagram of pathway enrichment analysis for bufalin-altered proteins in HepG2 cells. Blue dots represented markedly down-regulated proteins/pathways and red dots indicated significantly up-regulated proteins/pathways. e Statistical analysis of pathway enrichment. Gray columns plotting on the left Y-axis depicted the number of identified proteins found in each pathway. Yellow columns plotting on the right Y-axis depicted the percentage of identified proteins over total proteins.
