Fig. 8: PKM2 K433 acetylation is required for TSP50-induced tumor growth.
From: TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation
A–C Photography of xenograft tumor-bearing mice injected with different cell lines transfected. D, E Tumor volume and tumor weight for each group. F–I Expression of TSP50 and PKM2, lactate production and ATP levels were detected in tumor. J–L Photography of xenograft tumor-bearing mice injected with different cell lines transfected. M, N Tumor volume and tumor weight for each group. O–R Expression of TSP50 and PKM2, lactate production and ATP levels were detected in tumor. n = 6 in each group. All aerobic glycolysis values were normalized to protein levels. N = 3 biologically independent replicates. t-Test or one-way ANOVA statistical analysis was used. Data were presented as means ± s.d. *P < 0.05, **P < 0.01. ns, no significance.
