Fig. 2: Screening of small molecular inhibitor of APE1. | Cell Death & Disease

Fig. 2: Screening of small molecular inhibitor of APE1.

From: Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer

Fig. 2

a The schemata of AP site cleavage assay. b Chemical structure of NO.0449-0145. c Cell survival assay showed that NO.0449-0145 treatment induced cell death in A549, NCI-H460, NCI-H1299 cells but not in HELF cell. d Circular dichroism spectroscopy analysis of APE1/NO.0449-0145 binding. e Docking studies identified four high-potential sites of APE1 binding with NO.0449-0145. f Inhibitory effects of NO.0449-0145 on FEN1 mutations. Each experiment was repeated three times. **p < 0.01.

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