Fig. 6: NO.0449-0145 overcomes the cisplatin resistance of A549 cell. | Cell Death & Disease

Fig. 6: NO.0449-0145 overcomes the cisplatin resistance of A549 cell.

From: Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer

Fig. 6

a Cell survival assay in A549-DDP cells treated with NO.0449-0145 for 48 h. b Morphological analysis of different treated A549-DDP cells. c Representative Hoechst/PI fluorescence images of A549-DDP cells with different treatment. d Western blotting analysis of γ-H2AX in different treated A549-DDP cells. e Representative image of Immunofluorescence staining for γ-H2AX foci. f Drug sensitivity assay of A549-DDP cells following co-treatment with cisplatin and NO.0449-0145 or vehicle. The data are presented as the mean ± SD values, and the error bars represent data from triplicate biological experiments. *p < 0.05; **p < 0.01; ***p < 0.001.

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