Table 2 List of potential autophagy inhibitors.

From: High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol

Compound

Mean difference of mCit-LC3 (%)

SD

SSMD

P05D05

+2590.4a

±765.1

1.91

P05C04

+536.3

±294.2

1.03

P02D03

+336.7

±182.2

1.04

P05D10

+335.7

±85.5

2.21

P04C10

+256.2

±45.0

3.21

P01B11

+249.9

±38.4

3.67

P03B08

+243.9

±45.4

3.03

P01F02

+240.8

±49.9

2.72

P03B06

+235.2

±32.0

4.14

P05B05

+234.4a

±44.8

2.95

P01E05

+224.6

±19.1

6.65

P05E10

+221.8

±21.1

5.92

P01C06

+220.6

±37.8

3.29

P01F11

+209.4

±55.6

2.13

P01G06

+174.5

±21.1

4.67

P04E03

+174.3

±30.7

3.21

P02D05

+170.9

±67.0

1.44

P04E04

+166.1

±48.5

1.93

Arzanol

+164.6

±63.9

1.45

P01F08

+159.6

±45.8

1.97

P05B09

+158.8

±53.8

1.67

P01G09

+158.7

±52.9

1.69

P04D02

+158.2

±19.3

4.63

P05B06

+153.1

±69.7

1.24

P05B02

+149.6

±47.0

1.80

P05C03

+149.0

±32.9

2.55

P03F09

+138.3

±37.5

2.08

P02E04

+122.0

±63.9

1.08

P02F04

+105.1

±55.0

1.08

P04G07

+98.3

±29.4

1.88

P02B07

+93.7

±44.5

1.19

P04B04

+93.4

±34.7

1.52

P04B07

+87.2

±39.5

1.24

P04F06

+78.1

±19.0

2.32

P05E07

+67.4

±19.5

1.95

P04B02

+67.1

±15.6

2.43

P04G08

+66.9

±30.5

1.24

P02B02

+60.7

±25.1

1.36

P05F02

+59.4

±12.7

2.64

P03F08

+53.3

±13.2

2.28

P05F03

+46.0

±14.1

1.84

P01C05

+41.8

±16.6

1.42

P04C02

+40.0

±16.0

1.41

P02E08

+38.7

±3.4

6.44

P05E06

+36.9

±15.9

1.31

P04E10

+35.4

±17.2

1.16

P05C06

+34.8

±5.1

3.85

P03E07

+33.6

±17.6

1.08

P05D06

+33.2

±12.4

1.51

P05G05

+33.2

±2.4

7.93

P02D07

+32.1

±17.3

1.05

P05E04

+31.3

±6.8

2.59

P01G02

+29.8

±14.2

1.18

P04C11

+27.6

±5.6

2.76

P01C09

+25.1

±6.8

2.10

P05F04

+23.8

±7.2

1.86

P04B10

+23.1

±8.3

1.57

P05D07

+22.9

±5.5

2.36

P01E03

+22.0

±9.0

1.39

P05E02

+21.1

±4.0

3.01

P04E02

+18.2

±9.2

1.12

P04D04

+17.2

±8.0

1.21

P05B10

+17.2

±7.5

1.30

P03E06

+15.9

±3.5

2.56

  1. SD standard deviation, SSMD strictly standardized mean difference.
  2. aCould be caused by autofluorescence.
  3. In total, 64 compounds causing equal to or greater than 15% LC3 protection at a fairly moderate and higher effect (│SSMD score│ ≥1) at 10 µM after 6 h of treatment were classified as potential inhibitors of autophagy.
  4. Data show mean difference ± SD (% of control) of mCitrine-LC3 increase upon starvation medium monitored by flow cytometry.
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