Fig. 1: Tumor onset and histology analysis.
From: Oxytocin receptor induces mammary tumorigenesis through prolactin/p-STAT5 pathway
A Kaplan–Meier plot of tumor-free survival for wild-type (WT) (n = 29) and ++Oxtr females (n = 30). B Tumor incidence analysis, WT, n = 29 and ++Oxtr, n = 30. C Tumor growth measurement by volume (n = 9). D Tumor weights 30 days after palpation (n = 8). Data were represented as mean ± SD. ***P < 0.001, calculated using two-tailed unpaired t-test and Log-rank (Mantel–Cox) test. E Representative macroscopic view of tumors in ++Oxtr females. Scale bar: 1 mm. F Histology analysis of ++Oxtr mammary tumors. Representative images of H&E staining of mammary tumors showing major histological subtypes: a. Papillary carcinomas with squamous phenotype. b. Papillary carcinomas with mucus and lipid droplets. c. Medullary carcinomas. d. Glandular carcinomas. e. Poorly differentiated carcinoma. f. Clear cell carcinoma. Scale bar: 100 μm. Pie chart shows distribution of each subtype.
