Fig. 7: Role model of OXTR in mammary tumorigenesis.
From: Oxytocin receptor induces mammary tumorigenesis through prolactin/p-STAT5 pathway
OXTR overexpression leads to increased prolactin secretion in ++Oxtr females. Prolactin induces phosphorylation and nuclear translocation of p-STAT5 to promote transcription of genes responsible for cell proliferation and milk proteins (Csn2 and Wap). Excessive proliferation of mammary epithelium induces tumorigenesis.
