Fig. 1: Follow-up data analysis and sequencing data quality control.

a, b The Kaplan–Meier plots showed that the progression-free survival and overall survival of patients decreased significantly as the patients’ tumor stage increased. The significance was tested by Log-rank test. c Quality control for patients’ tumor (TT) or para-tumor (PT) tissue: the plot showed no significant different gene number sequenced in two groups. d Quality control for patients’ tumor (TT) or para-tumor (PT) tissues: library size sequenced showed no significant difference between two groups. e Quality control for patients’ tumor (TT) or para-tumor (PT) tissue: PCA clustering showed that there were significant differences between patients’ TT and TP tissues (12 samples each for TT or TP group).