Fig. 4: Effects of fasting on ACBP/DBI levels.

Fasting induces a decrease in BMI (A), an increase of ACBP/DBI (B) and a loss of the correlation between ACBP/DBI and BMI (C). Box and whisker plots representing BMI (kg/m2) (A) and ACBP/DBI levels (ng/mL) (B) before and after fasting in the BWC cohort. Scatter plots with regression lines between ACBP/DBI (ng/mL) and body mass index (kg/m2) (C) before and after fasting in the BWC cohort. Pearson’s correlation coefficient (R) and their p value and number of samples available (n) are shown in the legend of each panel. Note that the results of paired t tests limited to patients with complete BMI data (before and after fasting, n = 48) show a similar difference in terms of BMI decrease (p < 0.001) and DBI increase (p < 0.001).