Fig. 7: Anorexigenic effects of chemotherapy in mice.

A Scatter plot with regression line between ACBP/DBI (ng/mL) and weight (g) in mice with and without cancer. Pearson’s correlation coefficient (R) and their p value and number of samples available (n) are shown in the legend of each panel. B, C Metabolic effects in anorexic mice due to chemotherapy. Mice were treated with PBS or cisplatin (CDDP: 4 mg/kg) every week for 40 days. Body weight was monitored (B) and plasma ACBP levels were quantified on day 39 (C) (n = 8–10 mice per group). Body weight PBS versus CDDP p < 0.001. D, E Metabolic effects of ACBP expression in anorexic mice due to chemotherapy. Mice received hydrodynamic injections of empty pLIVE or pLIVE-ACBP (100 µg) expressing vector at day 2. Three days after, mice were treated with PBS or cisplatin (CDDP: 4 mg/kg) once per week. Body weight was monitored (D) and plasma ACBP concentrations were measured in the CDDP treated mice at day 8 (E) (n = 8–10 mice per group). Body weight pLIVE-empty PBS versus pLIVE-empty CDDP p < 0.001. Body weight pLIVE-empty PBS versus pLIVE-ACBP CDDP p = 0.75. Body weight pLIVE-empty CDDP versus pLIVE-ACBP CDDP p < 0.001.