Table 1 Univariate and multivariate Cox regression analyses for overall survival in PCa patients enrolled in tissue microarray.

From: HJURP promotes proliferation in prostate cancer cells through increasing CDKN1A degradation via the GSK3β/JNK signaling pathway

 

Univariable models

Multivariable models

Multivariable models

Variables

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age (years)

 ≤65

Ref.

 

Ref.

 

Ref.

 

 >65

11.60 (1.55, 86.75)

0.017

14.11 (1.67, 119.22)

0.015

13.31 (1.63, 108.51)

<0.001

Gleason grade group at RP

  

–

 

–

 

 1

Ref.

     

 2

0.49 (0.04, 5.44)

0.563

    

 ≥3

2.35 (0.31, 17.67)

0.408

    

Pathological T stage

    

–

 

 T2

Ref.

 

Ref.

   

 T3a

4.36 (1.47, 12.95)

0.008

0.79 (0.20, 3.10)

0.730

  

 T3b

9.17 (2.49, 33.86)

0.001

0.78 (0.16, 3.83)

0.758

  

Pathological N stage

 N0

Ref.

 

Ref.

 

Ref.

 

 N1

14.27 (4.74, 42.95)

<0.001

34.48 (6.67, 178.34)

<0.001

28.32 (7.89, 101.60)

<0.001

IRS of HJURP

 ≤6

Ref.

 

Ref.

 

Ref.

 

 >6

6.63 (1.94, 22.64)

0.003

5.84 (1.56, 21.85)

0.009

5.62 (1.53, 20.60)

0.009

Surgical margins

 Negative

Ref.

 

Ref.

 

Ref.

 

 Positive

6.01 (2.44, 14.84)

<0.001

11.12 (3.60, 34.31)

<0.001

10.38 (3.55, 30.42)

<0.001

  1. IRS immunoreactivity score, RP radical prostatectomy.
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