Fig. 5: In vivo formed CLS in lean mice show comparable inflammation marker expression to induced CLS. | Cell Death & Disease

Fig. 5: In vivo formed CLS in lean mice show comparable inflammation marker expression to induced CLS.

From: Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages

Fig. 5

Whole mount antibody staining of CLS formed in vivo in lean mice under homeostatic conditions. A–C ATMs in in vivo formed CLS express pro-inflammatory markers CD11c, CD86, and CD9, while interstitial ATMs are negative (highlighted by arrows). D, E Interstitial ATMs express the anti-inflammatory markers CD206 and CD301 (highlighted by arrows), while ATMs in CLS are negative. F, G Expression of CD64 (all macrophages) or TREM2 (highlighted by arrows). Asterisks mark adipocytes inside CLS. Scale bars = 100 µm.

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