Fig. 1: Workflow to describe SARS-CoV-2 host interactome analysis based on PPI data. | Cell Death & Disease

Fig. 1: Workflow to describe SARS-CoV-2 host interactome analysis based on PPI data.

From: Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2–host interactome

Fig. 1

Human-human PPI database has been merged with Host-SARS-CoV-2 PPIs databases and then an explorative algorithm (Random Walk with Restart) was applied in order to identify host response to SARS-CoV-2 infection, pathways modulations induced by specific SARS-CoV-2 protein and link with pathogenic conditions in COVID-19.

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