Fig. 4: PPI interactome based on human PPI and SARS-CoV-2-host interactions, with top 200 closest proteins identified by RWR, using Kininogen-1 as seed. | Cell Death & Disease

Fig. 4: PPI interactome based on human PPI and SARS-CoV-2-host interactions, with top 200 closest proteins identified by RWR, using Kininogen-1 as seed.

From: Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2–host interactome

Fig. 4

A PPI Intercatome, where larger nodes and edges in red represent interactions via NS7b and ORF3a-ECE1-KNG1 (BK). The nodes in red are human proteins, while the nodes in green are virus proteins. B KEGG human pathway and WikiPathways Gene Enrichment analyses for 200 proteins closest to KNG-1. C PPI interactome, where proteins belonged to Human Complement System WP2806 (modes in purple) and, Complement and coagulation cascades (nodes in blue) pathways were highlighted. The proteins that belonged to both pathways were marked in light blue. The nodes in red are human proteins, while the nodes in green are virus proteins.

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