Fig. 1: Live-dead decision of MSCs in therapy.
From: Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy
After infusion, exgenous MSCs in the undetermined condition confront with the stimuli of multiple factors inculding immunological, metabolic, and other cues. Subsequently, the MSCs can be alive to exert therapeutic effects based on differentiation and secretion, which also can undergo apoptosis to regulate immune responses. ApoEVs have been demonstrated to be a noval and potent therapeutic in translational medicine. The above condition of live-dead decision for infused MSCs based on current recognitions has emerged as a representative paradigm of Taichi.
