Fig. 2: LncRNA-mRNA co-expression networks during the pathogenesis of IPF.
From: LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation
A IPF pathogenic lncRNAs (diamond)-mRNAs (oval) co-expression network in IPF. The nodes marked with red color represent the up-regulated IPF pathogenic genes. The nodes marked with blue color represent the down-regulated IPF pathogenic genes. The solid lines (dotted lines) represent the positive (negative) correlation between mRNAs and lncRNAs (|r| >0.8, P < 0.01, Pearson Correlation Test). B Distribution of the degree of genes in the IPF pathogenic network. C Circos plots display chromosomal interactions between co-expressed lncRNAs and mRNAs. The location of lncRNA CTD-2528L19.6 was marked with red arrows. D, E KEGG pathways enrichment with IPF pathogenic up-regulated mRNAs (D) or down-regulated mRNAs (E). FDR < 0.05, Hypergeometric test. Size of the bubble indicates the number of genes in the corresponding annotation. Color shade corresponds to the -log10(p) value. The closer the color is to red, the more significant the enrichment is.
