Fig. 8: NETs induce intestinal barrier injury through the TLR9–ER stress–ROS signaling pathway. | Cell Death & Disease

Fig. 8: NETs induce intestinal barrier injury through the TLR9–ER stress–ROS signaling pathway.

From: Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway

Fig. 8

In the case of sepsis, increased neutrophils migrate and aggregate in the intestine and trigger NETosis. Excessive NETs formation can activate the TLR9–ER stress–ROS signaling pathway, which enhances intestinal epithelial cell apoptosis and the inflammatory response. Uncontrolled intestinal epithelial cell injury results in intestinal barrier disruption, leading to bacterial translocation.

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