Fig. 6: Loss of p63 (not p53 and p73) partially rescued Thaps. induced apoptosis at early embryonic stage.
From: Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis
A Loss of p63 partially rescued Thaps. induced apoptosis at 24 hpf. Ratio of phenotypic categories of the apoptotic severity in wild type, tp63−/−, sibling tp63+/− and sibling tp63+/+ zebrafish embryos at 4 h after DMSO or Thaps. treatment. Embryos from the intercross of heterozygous-mutant tp63 adults were genotyped after sorted based on the apoptotic severity at tail region. B Loss of p53 and p73 cannot rescue Thaps. induced apoptosis at 24 hpf. Ratio of phenotypic categories in 24 hpf wild-type and tp53−/− tp73−/− zebrafish embryos at 4h after DMSO or Thaps. treatment. n = 6 (A) and n = 4 (B) from pooled embryos per sample. The total number of Thaps treated embryos: wild type > 660, tp63−/− > 360, tp63+/− > 700, tp63+/+ > 320 and tp53−/− tp73−/− > 420. Bars represent mean ± SEM. ****p < 0.0001.
