Fig. 8: p63, but not p53 and p73, are required for PMA-induced apoptosis. | Cell Death & Disease

Fig. 8: p63, but not p53 and p73, are required for PMA-induced apoptosis.

From: Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

Fig. 8

A Percentage of phenotypic apoptotic categories in wild type, tp63−/−, sibling tp63+/−, and sibling tp63+/+ zebrafish embryos at 4 h after treatment with DMSO or PMA. B Percentage of phenotypic categories in 24 hpf wild type and tp53−/− tp73−/− zebrafish embryos at 4 h after DMSO or PMA treatment. n = 6 (A) and n = 5 (B) from pooled embryos per sample. The total number of Thaps treated embryos: wild type > 600, tp63−/− > 140, tp63+/− > 390, tp63+/+ > 180, and tp53−/− tp73−/− > 370. Bars represent mean ± SEM. ****p < 0.0001.

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