Fig. 2: Hsa_circ_0110389 promotes the proliferation, migration and invasion of GC cells in vitro. | Cell Death & Disease

Fig. 2: Hsa_circ_0110389 promotes the proliferation, migration and invasion of GC cells in vitro.

From: Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Fig. 2

A Expression of hsa_circ_0110389 was significantly decreased in HGC-27 and KATO III cells after transfection of sh-hsa_circ_0110389. B Expression of hsa_circ_0110389 was significantly increased in AGS and NCI-N87 cells after transfection of hsa_circ_0110389 overexpression plasmids. C CCK-8 results showed that knockdown of hsa_circ_0110389 suppressed HGC-27 and KATO III cell proliferation. D CCK-8 results showed that overexpression of hsa_circ_0110389 promoted AGS and NCI-N87 cell proliferation. E EdU staining results showed that knockdown of hsa_circ_0110389 suppressed HGC-27 and KATO III cell proliferation. F EdU staining results showed that overexpression of hsa_circ_0110389 promoted AGS and NCI-N87 cell proliferation. G Colony formation results showed that knockdown of hsa_circ_0110389 suppressed HGC-27 and KATO III cell growth in vitro. H Colony formation results showed that overexpression of hsa_circ_0110389 promoted AGS and NCI-N87 cell growth in vitro. I Wound healing assay of HGC-27 and KATO III cells transfected with sh-hsa_circ_0110389 or control. J Wound healing assay of AGS and NCI-N87 cells transfected with hsa_circ_0110389 overexpression or control plasmids. K Transwell-invasion assay of HGC-27 and KATO III cells transfected with sh-hsa_circ_0110389 or control. L Transwell-invasion assay of AGS and NCI-N87 cells transfected with hsa_circ_0110389 overexpression or control plasmids. All data are presented as mean ± SD. **P < 0.01, ***P < 0.001.

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