Fig. 7: Knockdown of hsa_circ_0110389 inhibits growth of GC tumor in vivo. | Cell Death & Disease

Fig. 7: Knockdown of hsa_circ_0110389 inhibits growth of GC tumor in vivo.

From: Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Fig. 7

A–C Schematic representation (A), in vivo growth curve (B), and weight at the end points (C) of xenograft tumors formed by subcutaneous injection of HGC-27 and KATO III cells stably transfected with sh-NC or sh-circRNA (n = 5 for each group). D Representative images of H&E staining, Ki-67 staining and IHC for SORT1 of xenograft tumors. E The RNA levels of hsa_circ_0110389, miR-127-5p and miR-136-5p in xenograft tumors were detected by qRT-PCR. F The protein levels of SORT1 and autophagy-related genes (Beclin-1, LC3B and p62) in xenograft tumors by western blot. G The expression of LC3B in xenograft tumors by IF analysis. All data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.

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