Fig. 2: Upregulated circPDE3B was positively correlated with the poor prognosis of ESCC.

The correlation between circPDE3B expression lever and TNM stage (A), lymph node metastasis (B), and histological grade (C) of ESCC patients. D The univariate Cox proportional hazards analysis was performed to depict the correlations between the indicated clinical criteria and disease-free survival rate. Patients with higher circPDE3B expression had a shorter overall survival time (E) and disease-free survival time (F) than those with lower circ-circPDE3B expression. *p < 0.05, **p < 0.01, ***p < 0.001.