Fig. 3: PLK4 inhibition induces DNA damage in DLBCL cell lines. | Cell Death & Disease

Fig. 3: PLK4 inhibition induces DNA damage in DLBCL cell lines.

From: Inhibition of Polo-like kinase 4 induces mitotic defects and DNA damage in diffuse large B-cell lymphoma

Fig. 3

a Representative immunofluorescence micrograph showed increased γ-H2AX expression in the DLBCL cell nucleus at 48 h after CFI-400945 treatment. Scale bar: 5 μm. b Quantification of γ-H2AX intensity. c CFI-400945 activated the DNA damage sensing ATM and ATR pathway. LY8 and LY3 cells were treated with CFI-400945 at the doses indicated for 48 h. Data are shown as the mean ± SD, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001.

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