Fig. 5: Comparison of the C26 model with integrative data and gene validation. | Cell Death & Disease

Fig. 5: Comparison of the C26 model with integrative data and gene validation.

From: An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models

Fig. 5

A The Venn plot shows the overlap of 127 upregulated DEGs and 126 downregulated ‘DEGs in the C26 model with merged data. B The top 25 predominately enriched pathways of upregulated and downregulated genes in the merged dataset and C26 dataset were compared. C Validation of the upregulated and downregulated DEGs in the enriched KEGG pathways in the merged dataset was performed by qPCR. Data are expressed as the mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, N = 10.

Back to article page