Fig. 6: The protein interaction network revealed Ddit4 as a key protein in cancer cachexia. | Cell Death & Disease

Fig. 6: The protein interaction network revealed Ddit4 as a key protein in cancer cachexia.

From: An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models

Fig. 6

A The protein-protein interaction (PPI) network of upregulated genes in the enriched KEGG pathways was constructed according to their biological association. The color of the node indicates the degree of the gene, and the circle and font size of the node indicates the number of direct edges. B The expression of Ddit4 in each cachexia model. C The expression of Ddit4 in other muscle atrophy models such as denervated, fasting, immobilization, Huntingdon disease, and rapamycin-treated mice. D All enriched pathways of upregulated and downregulated genes in cachexia and degenerative conditions such as fasting and denervation were compared.

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