Fig. 1: Worse prognostic significance of USP22 overexpression in iCCA. | Cell Death & Disease

Fig. 1: Worse prognostic significance of USP22 overexpression in iCCA.

From: Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma

Fig. 1

A RNAs from paired iCCA and adjacent normal tissues from individual patients (n = 57) were respectively extracted and quantified for USP22 mRNA expression by qPCR. B Levels of USP22 mRNA were higher in iCCA than the adjacent normal tissues (NT) (n = 57) (*p < 0.05), particularly those with metastatic tumours (MT) (n = 27) vs non-metastatic tumours (NMT) (n = 30) (p < 0.05). C IHC for USP22 in iCCA and the adjacent normal tissue sections were performed, showing the nuclear localisation of UPS22 (scale bar = 100 µM or 200 µM). D High scores of USP22 expression were significantly elevated in iCCA tissues, particularly in MT (n = 27) vs NT (n = 57) or NMT (n = 30) (*p < 0.05). E Kaplan–Meier survival curves showed a significant correlation of the high USP22 group (n = 16) with worse overall survival than the low expression group (n = 41) (*p < 0.05).

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