Fig. 3: Knockdown of PSMC2 inhibits tumorigenesis and tumor growth of breast cancer in vivo. | Cell Death & Disease

Fig. 3: Knockdown of PSMC2 inhibits tumorigenesis and tumor growth of breast cancer in vivo.

From: Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU)

Fig. 3

A In vivo imaging was performed to observe the tumor forming and growth in vivo. B The fluorescence intensity of tumor detected in animal imaging was scanned and quantified as a representation of tumor burden. C The measurement and calculation of tumor volume were carried out throughout animal culturing and showed that tumors formed by PSMC2 knockdown cells grew much slower. D The tumors formed by PSMC2 knockdown cells were significantly lighter than that formed by shCtrl cells. E The histological characteristics and Ki67 expression of the tumors formed in shPSMC2 or shCtrl group were examined by H&E staining and IHC, respectively. Data were shown as mean ± SD (n ≥ 3). * P < 0.05, * P < 0.01, *** P < 0.001.

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