Fig. 4: Mettl3 knockout results in more severe translational dysregulation than Fto deletion.

A Pie charts of ribosome distributions in coding sequence (CDS) of mRNA transcripts, noncoding RNAs (ncRNAs), and pseudogenes in E15.5 control (Ctrl), F-cKO, and M-cKO cortices detected by ribosome profiling sequencing (Ribo-seq). B Venn diagram of differentially expressed mRNAs between M-cKO and F-cKO. C Gene Ontology (GO) enrichment analyses of differentially expressed mRNAs between M-cKO and F-cKO. D Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of mRNAs that show significantly differential expression (Padj < 0.05) in M-cKO (Red) and F-cKO (green) cortices.