Fig. 7: Knockout of Mettl3 alters expression levels of major components in m6A methylation. | Cell Death & Disease

Fig. 7: Knockout of Mettl3 alters expression levels of major components in m6A methylation.

From: Distinct roles of Fto and Mettl3 in controlling development of the cerebral cortex through transcriptional and translational regulations

Fig. 7

A Integrative Genomics Viewer (IGV) images of expression patterns (left) and expression quantifications (right) of Mettl3, Mettl16, and Wtap in E15.5 control (Ctrl), F-cKO, and M-cKO cortices detected by RNA-seq and Ribo-seq. B Expression patterns (left) and quantifications (right) of demethylases of Fto and Alkbh5. C Expression patterns (left) and quantifications (right) of Ythdc1, Ythdf1, and Ythdf2. Error bars indicate the SEM (three independent samples). P values were calculated by Student’s t-test between Ctrl and F-cKO or Ctrl and M-cKO. P values: *P < 0.05; **P < 0.01; ***P < 0.001.

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