Fig. 5: PGE2-JNK signaling axis promotes intestinal tumor growth by non-canonically stimulating Hh activity in a Smo-independent manner in ApcMin/+ mice. | Cell Death & Disease

Fig. 5: PGE2-JNK signaling axis promotes intestinal tumor growth by non-canonically stimulating Hh activity in a Smo-independent manner in ApcMin/+ mice.

From: PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation

Fig. 5

A, B The intestinal polyp number and size in ApcMin/+ mice treated with PGE2,GDC,SP, and JQ1 as indicated for 2 months. Error bars represent SD (n = 6). C The mRNA levels of Gli target genes in small intestine of mice treated with PGE2, GDC, SP, and JQ1 as indicated for 2 months. Error bars represent SD (n = 6). D Schematic model depicting the activation of Hh signaling pathway in cancer cells and stromal cells in colorectal cancer.

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