Fig. 6: Phosphorylated JNK and Gli2T1546 are correlated with Gli2 expression in colorectal cancer. | Cell Death & Disease

Fig. 6: Phosphorylated JNK and Gli2T1546 are correlated with Gli2 expression in colorectal cancer.

From: PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation

Fig. 6

A H&E staining and IHC staining of the primary human CRC tissue microarray. Scale bar, 50 μm. B Scatter plot showing the Gli2, p-Gli2T1546, p-JNK, and ki-67 staining level in individual tumors as a ratio of staining in CRC versus paired non-cancer tissue. n = 86. C Correlation plot of p-Gli2T1546 and Gli2 IHC staining (arbitrary units). Correlation was evaluated by nonparametric Spearman test. The coefficient of correlation (r), and the p value (p) are indicated. n = 86. D Correlation plot of p-JNK and Gli2 IHC staining (arbitrary units). Correlation was evaluated by nonparametric Spearman test. The coefficient of correlation (r), and the p value (p) are indicated. n = 86. E Correlation plot of ki-67 and Gli2 IHC staining (arbitrary units). Correlation was evaluated by nonparametric Spearman test. The coefficient of correlation (r), and the p value (p) are indicated. n = 86. F Kaplan–Meier survival analysis of CRC cases separated into two groups by the median value for phospho-Gli2T1546 staining. The p value was calculated by log rank test.

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