Fig. 2: Enriched irradiation-resistant genes from the genome-scale CRISPR/Cas9 activation screen in GBM. | Cell Death & Disease

Fig. 2: Enriched irradiation-resistant genes from the genome-scale CRISPR/Cas9 activation screen in GBM.

From: Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma

Fig. 2

A Significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for genes with sgRNA diversity >3 in irradiation-resistant GBM cells. B The genes with the top 10% of sgRNA abundance in GBM cells (Supplementary Table S2) were intersected and were then used for KEGG pathway analysis. C Kaplan–Meier analysis indicated that GBM patients with high expression of CARHSP1, KIAA0895, FBMIL1, and STRA6 exhibited worse overall survival. D CARHSP1, FBMIL1, and STRA6 mRNA expression were selectively upregulated in GBM compared with the Normal (GEPIA).

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