Fig. 6: Inhibition of TNF-α could increase the sensitivity of GBM cell to radiotherapy. | Cell Death & Disease

Fig. 6: Inhibition of TNF-α could increase the sensitivity of GBM cell to radiotherapy.

From: Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma

Fig. 6

A Correlation analysis of CARHSP1 and TNF-α by the mRNA data in TCGA. B qPCR was used to detect the TNF-α mRNA level in CARHSP1 knockdown and overexpression GBM cells. C The U87 and U251 cells were treated with TNFα stimulator (Resiquimod, 1 μM) for 24 h or transfected with TNFα knockout plasmid. CCK8 assay was used to measure cell viability of TNFα stimulator and knockout cells when treated with 0, 6, 12, and 18 Gy/min irradiation. Data were represented as means ± SD of three independent experiments.

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