Fig. 5: PLEKHO2 deficiency in mice leads to increased hepatoxicity and lethality in response to TNFα in vivo. | Cell Death & Disease

Fig. 5: PLEKHO2 deficiency in mice leads to increased hepatoxicity and lethality in response to TNFα in vivo.

From: PLEKHO2 inhibits TNFα-induced cell death by suppressing RIPK1 activation

Fig. 5

A Age- and sex-matched WT and PLEKHO2−/− mice were injected intraperitoneally with TNFα (2.5 ng/g body weight) plus d-galactosamine (0.8 μg/g body weight). Survival was monitored every hour for 36 h (*p < 0.05, one-way ANOVA). B Mice were treated as A, serum AST and ALT enzyme levels were measured 6 h after TNFα/d-GalN injection. C, E Mice were treated as A, 6 h after, hepatic tissue was collected, sectioned, and subjected to histological analysis using H&E (C), WB analysis (D), and TUNEL staining (E).

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