Fig. 6: miR-4293 and WFDC21P promote tumorigenesis in vivo. | Cell Death & Disease

Fig. 6: miR-4293 and WFDC21P promote tumorigenesis in vivo.

From: miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation

Fig. 6

miR-4293 transfection elevated miR-4293 level, which could be reduced by ASO. pcDNA-WFDC21P increased WFDC21P and Si-WFDC treatment reduced WFDC21P level. a–c Analysis of xenograft of A549 cells treated with pc-DNA or pcDNA-WFDC21P (n = 4). Quantitative analysis of tumor volume (b) and tumor weight (c) of xenografts. The xenografts of each group were weighed and data were expressed as median (interquartile range). *p < 0.05; Mann-Whitney U t-test. d–f Analysis of xenograft tumors of miR-4293-, si-WFDC-, and scramble-treated A549 cells (n = 4). Quantitative analysis of tumor volume (e) and tumor weight (f) of xenografts. Data are expressed as median (interquartile range). **p < 0.01, *p < 0.05; Kruskal-Wallis H test. g–i Analysis of xenograft tumors of miR-4293-, miR-4293+ASO-4293- and miR-4293+WFDC-treated A549 cells (n = 5). Quantitative analysis of tumor volume (h) and tumor weight (i) of xenografts. Data are expressed as median (interquartile range). **p < 0.01, *p < 0.05; Kruskal-Wallis H test. j–l Analysis of xenograft tumors of A549 cells treated with pcDNA-WFDC21P + ASO-4293 or pcDNA-WFDC21P + scramble (n = 3). Quantitative analysis of tumor volume (k) and tumor weight (l) of xenografts. Data are expressed as median (interquartile range). **p < 0.01; Mann-Whitney U t-test.

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