Fig. 7: miR-4293 regulating WFDC21P through DCP-2. | Cell Death & Disease

Fig. 7: miR-4293 regulating WFDC21P through DCP-2.

From: miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation

Fig. 7

miR-4293 promotes tumor cell proliferation and metastasis but suppresses apoptosis. DCP2 can directly or indirectly bind to and downregulate WFDC21P. By targeting DCP2 mRNA, miR-4293 suppresses the expression of DCP2, and further enhances the expression of WFDC21P and promotes STAT3 phosphorylation. As a result of elevated STAT3 activity, apoptosis is suppressed and proliferation is enhanced through Bcl2 elevation, Bax2 attenuation and reduced caspase cleavage. In addition, WFDC21P elevates miR-4293 expression by promoting STAT3 activation.

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